Emily Johnson, her boyfriend Bobby and their friends Clare and Jude are recent college grads driving cross-country, taking a last vacation together before they face the “real” world. An accident leaves them hurt and stranded on a lonely Louisiana road.

When the ambulance arrives, it whisks them to Charity Hospital. With a minimal staff and many of its floors empty, the hospital is an eerie place…but that’s only the beginning. The staff is conducting inhuman experiments on helpless patients under the instruction of Dr. Benway, a direct descendant of the infamous New Orleans family that committed atrocities in the 19th century.